《胃癌预警和早期诊断系统(英文版)》系“转化医学出版工程:技术系列”之一,是关于纳米技术应用于胃癌早期检测系统的研究,主要内容包括胃癌标志物的筛选与鉴定;胃癌标志物超敏感特异性检测方法与诊疗器械研发;纳米粒子的制备与胃癌靶向成像与治疗一体化的多功能纳米探针的研制与应用;胃癌标志物快速检测传感器器件的研发与临床转化;胃癌循环血癌细胞的捕获与定量设备的研发;胃癌十细胞靶向成像与治疗的进展;胃痛细胞免疫治疗的进展;胃癌纳米探针的安全性评价与临床转化;原位胃癌分子分型的研究现状与指导靶向治疗药物的筛选;胃痛预警数据库和影像数据库的进展;胃癌预警与早期诊断系统临床转化的技术前景。
《胃癌预警和早期诊断系统(英文版)》是一本多学科交义研究的结果总结,同时也对相关的研究进展进行了综述,对研究生、从事胃癌研究的人员以及临床医师都具有极高的参考价值与指导意义。
Over the years, a chasm between biomedical researchers and the patients who may benefit from their discoveries has been opened. On one hand, millions of patients with diseases such as cancer are anxiously waiting for new remedies to save their lives. On the other hand, many exciting basic science discoveries do not have opportunities to find practical applications. Recently emerging translational medicine aims to tie basic research to clinical results and optimize both patient care and preventive measures.
Translational medicine converts promising laboratory discoveries into clinical applications and elucidates clinical questions with the use of bench work, aiming to facilitate prediction, prevention, diagnosis, and treatment of diseases. With the ultimate goal to develop more effective preventive/therapeutic approaches and improve clinical outcomes and health levels, translational medicine is therefore a people (patients and the general population as a whole)-oriented medical practice.
The past three decades have witnessed tremendous advances in China in the development of living conditions, food and nutrition, and the health care system. However, while the economy grows and society rapidly transforms, the health care system faces multiple problems. China bears a complex disease spectrum: On one hand, communicable diseases frequently seen in developing countries remain a heavy burden; on the other hand, chronic diseases commonly found in developed countries are also the leading causes of death and disability in China. The situation shows that the health care system in China is facing great challenges, and a state effort is needed to meet these challenges. Therefore China is deepening its reform to improve its people's welfare. The development of translational medicine will accelerate disease control and finding solutions for health problems.
Translational medicine is a multidisciplinary program that integrates research from the medical sciences, basic sciences, and social sciences, with the aim of optimizing patient care and preventive measures that may extend beyond health care services. Therefore, close collaboration in an international scale among all the parties is essential to the development of translational medicine.
To enhance the aforementioned international collaboration as well as to provide a forum for communication and cross-fertilization among basic, translational, and clinical research practitioners, we launch the book series "Translational Medicine Research". It features original and observational investigations in the broad fields of laboratory, clinical, and public health research, aiming to provide practical upto-date information in significant research from all subspecialr.ies of medicine and to broaden t.he readers' vision and horizon from bench to bed and bed to bench.
In close collaboration with National Infrastructures for Translational Medicine (Shanghai), the book series "Translational Medicine Research" serves as a stateof-the-art resource Of physicians and translational medical researchers alike who are int.erested in the rapidly evolving field of translational medicine. As the Editor- in-Chief, I welcome all the researchers in related areas to report the latest bench- to-bedside researches in this series, so that the series can promote human health by accelerating the knowledge dissemination in global community.
1 Background of Gastric Cancer Prewarning and Early Diagnosis System
Daxiang Cui
2 Human Serum Protein Markers for Gastric Cancer Detection
Hualin Fu and Daxiang Cui
3 Screening and Detection of Gastric Cancer Circulating MicroRNA Biomarkers
Zhang Jingpu and Daxiang Cui
4 Screening and Identification of Biomarkers from Gastric Cancer Saliva Metabolites
Shangli Cheng and Daxaing Cui
5 Metabolic Profiles and High-Accuracy Diagnosis Model Based on Plasma Metabolomics of Gastric Cancer Patients
Cheng Shangli and Daxiang Cui
6 Identification of Volatile Organic Compound Biomarkers Associated with Gastric Cancer Cells and Their Ultrasensitive Electrochemical Detection
Yixia Zhang and Daxiang Cui
7 A Breath Analysis Based on SERS Sensor to Distinguish Patients with Early and Advanced Stages of Gastric Cancer from Healthy People
Yunsheng Chen and Daxiang Cui
8 The Application of Immunochromatographic Analysis in Early Detection of Gastric Cancer
Kan Wang and Daxiang Cui
9 Applications of Magnetic Nanoparticle-Based High-Throughput Single-Nucleotide Polymorphism Genotyping Platforms in Gastric Cancer Research
Song Li, Hongna Liu, and Nongyue He
10 Single-Cell Manipulation Technology for Cancer Research
Shujing Lin, Di Chen, and Yao Xie
11 Multifunctional Nanoprobes for Theranostics of Gastric Cancer.
Daxiang Cui
12 Upconversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy
Yuming Yang and Daxiang Cui
13 Stem Cells and Gastric Cancer
Meng Yang and Daxiang Cui
14 Safety Assessment of Nanoprobes
Yanlei Liu, Yuxia Wang, and Daxiang Cui
15 Gastric Cancer Prewarning Database and Bioinformatics Analysis
Cheng Shangli and Daxiang Cui