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兽药多组分残留分析技术 
定 价：298 元
9 7 4 8 7 7 7 0 3 3 1 0 6 读者对象:本科生、研究生及大专院校、科研单位、质检机构等各类从事食品安全检测技术研究与实际检验专业技术人员 
全书共分二十章，分别介绍了1苯乙胺（β-受体激动剂）类药物β-Adrenoceptoragonists、2磺胺类药物Sulfonamides、3氨基糖苷类药物aminoglycoside、4氯霉素类药物Chloramphenicol、5β-内酰胺类药物β-lactams、6大环内酯类（macrolides）和林可霉素类药物、7硝基呋喃类代谢物Nitrofurans、8甾类同化激素anabolicsteroids、9非甾类同化激素类药物inanabolicsteroids、10糖皮质激素类药物glucocorticoid、11氟喹诺酮类药物fluoroquinolone、12四环素类药物Tetracyclines、13镇静剂类药物sedative、14吡唑酮类药物Pyrazolone、15喹?f啉类药物quinoxaline、16硝基咪唑类药物Nitroimidazole、17苯并咪唑类药物、18咪唑并噻唑类药物、19硫脲嘧啶类药物Thiourea、20聚醚类药物等200多种兽药化合物多组分残留检测技术。每章分别概述了该类化合物理化性质和用途、代谢和毒理学、各国限量以及分析技术进展，重点介绍了一次制备样品可同时提取净化多种兽药化合物残留的样品制备技术和GC-MS和LC-MS/MS高通量检测技术，这些内容充分体现了当代国际兽药化合物残留分析技术的研究进展。全书内容全面、技术先进，既有现代分析技术详尽的理论介绍，又有兽药多组分残留分析的应用实例；既综合论述了当前国际上兽药检测技术发展现状，又全面介绍了我国兽药多组分残留检测的最新进展。
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目录
前言 1β-受体激动剂类药物1 1.1概述1 1.1.1理化性质与用途1 1.1.2代谢和毒理学6 1.1.3最大允许残留限量7 1.1.4残留分析技术7 1.2公定方法15 1.2.1河豚鱼、鳗鱼、烤鳗、牛奶和奶粉中12种β-受体激动剂类药物残留量的测定液相色谱-串联质谱法15 参考文献25 2磺胺类药物27 2.1概述27 2.1.1理化性质与用途27 2.1.2代谢和毒理学27 2.1.3最大允许残留限量31 2.1.4残留分析技术33 2.2公定方法49 2.2.1河豚鱼、鳗鱼中18种磺胺残留量的测定液相色谱-串联质谱法49 2.2.2蜂王浆中18种磺胺残留量的测定液相色谱-串联质谱法57 2.2.3畜禽肉中16种磺胺残留量的测定液相色谱-串联质谱法62 2.2.4蜂蜜中16种磺胺残留量的测定液相色谱-串联质谱法67 2.2.5牛奶和奶粉中16种磺胺残留量的测定液相色谱-串联质谱法72 参考文献79 3氨基糖苷类药物86 3.1概述86 3.1.1理化性质与用途86 3.1.2代谢和毒理学88 3.1.3最大允许残留限量89 3.1.4残留分析技术90 3.2公定方法100 3.2.1奶粉、牛奶、河豚鱼、鳗鱼和蜂王浆中链霉素、双氢链霉素和卡那霉素残留量的测定液相色谱-串联质谱法100 3.2.2蜂蜜中链霉素、双氢链霉素和卡那霉素残留量的测定液相色谱-串联质谱法108 参考文献110 4氯霉素类药物115 4.1概述115 4.1.1理化性质与用途115 4.1.2代谢和毒理学116 4.1.3最大允许残留限量118 4.1.4残留分析技术118 4.2公定方法143 4.2.1河豚鱼、鳗鱼和烤鳗中氯霉素、甲砜霉素和氟苯尼考残留量的测定液相色谱-串联质谱法143 4.2.2可食动物肌肉、肝脏和水产品中氯霉素、甲砜霉素和氟苯尼考残留量的测定液相色谱-串联质谱法149 参考文献153 5β-内酰胺类药物161 5.1概述161 5.1.1理化性质与用途161 5.1.2代谢和毒理学165 5.1.3最大允许残留限量166 5.1.4残留分析技术166 5.2公定方法180 5.2.1畜禽肉中9种青霉素残留量的测定液相色谱-串联质谱法180 5.2.2牛奶和奶粉中9种青霉素残留量的测定液相色谱-串联质谱法187 5.2.3河豚鱼和鳗鱼中9种青霉素残留量的测定液相色谱-串联质谱法193 5.2.4蜂蜜中6种青霉素残留量的测定液相色谱-串联质谱法198 5.2.5蜂蜜中5种头孢菌素残留量的测定液相色谱-串联质谱法204 5.2.6河豚鱼和鳗鱼中5种头孢菌素残留量的测定液相色谱-串联质谱法210 5.2.7牛奶和奶粉中4种头孢菌素残留量的测定液相色谱-串联质谱法213 参考文献216 6大环内酯类和林可胺类药物220 6.1概述220 6.1.1理化性质与用途222 6.1.2代谢和毒理学223 6.1.3最大允许残留限量225 6.1.4残留分析技术228 6.2公定方法236 6.2.1畜禽肉中9种大环内酯类和林可胺类药物残留量的测定液相色谱-串联质谱法236 6.2.2蜂蜜中8种大环内酯类和林可胺类药物残留量的测定液相色谱-串联质谱法243 6.2.3蜂王浆和蜂王浆冻干粉中8种大环内酯类和林可胺类药物残留量的测定液相色谱-串联质谱法249 6.2.4河豚鱼、鳗鱼中8种大环内酯类和林可胺类药物残留量的测定液相色谱-串联质谱法255 6.2.5牛奶和奶粉中6种大环内酯类药物残留量的测定液相色谱-串联质谱法261 参考文献266 7硝基呋喃类代谢物271 7.1概述271 7.1.1理化性质与用途271 7.1.2代谢和毒理学272 7.1.3最大允许残留限量274 7.1.4残留分析技术274 7.2公定方法282 7.2.1动物源食品中硝基呋喃类代谢物残留量的测定液相色谱-串联质谱法282 参考文献294 8甾类同化激素类药物298 8.1概述298 8.1.1理化性质与用途298 8.1.2代谢和毒理学303 8.1.3最大允许残留限量303 8.1.4残留分析技术304 8.2公定方法321 8.2.1牛肝和牛肉中睾酮、表睾酮、孕酮残留量的测定液相色谱-串联质谱法321 8.2.2牛奶和奶粉中醋酸美仑孕酮、醋酸氯地孕酮和醋酸甲地孕酮残留量的测定液相色谱-串联质谱法326 8.2.3牛奶和奶粉中α-群勃龙、β-群勃龙、19-乙烯去甲睾酮和epi-19-乙烯去甲睾酮残留量的测定液相色谱-串联质谱法330 8.2.4牛肌肉、肝、肾中的α-群勃龙、β-群勃龙残留量的测定液相色谱-串联质谱法336 8.2.5牛尿中α-群勃龙、β-群勃龙、19-乙烯去甲睾酮和epi-19-乙烯去甲睾酮残留量的测定液相色谱-串联质谱法340 参考文献345 9非甾类同化激素类药物350 9.1概述350 9.1.1理化性质与用途350 9.1.2代谢和毒理学352 9.1.3最大允许残留限量354 9.1.4残留分析技术354 9.2公定方法369 9.2.1牛猪肝肾和肌肉组织中玉米赤霉醇、玉米赤霉酮、己烯雌酚、己烷雌酚、双烯雌酚残留量的测定液相色谱-串联质谱法369 9.2.2牛尿中玉米赤霉醇、己烯雌酚、己烷雌酚、双烯雌酚残留量的测定液相色谱-串联质谱法376 9.2.3河豚鱼、鳗鱼和烤鳗中玉米赤霉醇、玉米赤霉酮、己烯雌酚、己烷雌酚、双烯雌酚残留量的测定液相色谱-串联质谱法379 9.2.4牛奶和奶粉中玉米赤霉醇、玉米赤霉酮、己烯雌酚、己烷雌酚、双烯雌酚残留量的测定液相色谱-串联质谱法384 9.2.5动物源性食品中玉米赤霉醇残留量的测定液相色谱-串联质谱法389 参考文献393 10糖皮质激素类药物398 10.1概述398 10.1.1理化性质与用途398 10.1.2代谢和毒理学401 10.1.3最大允许残留限量401 10.1.4残留分析技术402 10.2公定方法412 10.2.1河豚鱼、鳗鱼及烤鳗中9种糖皮质激素残留量的测定液相色谱-串联质谱法412 参考文献419 11喹诺酮类药物423 11.1概述423 11.1.1理化性质与用途423 11.1.2代谢和毒理学429 11.1.3最大允许残留限量430 11.1.4残留分析技术433 11.2公定方法447 11.2.1鳗鱼及制品中15种喹诺酮类药物残留量的测定液相色谱-串联质谱法447 11.2.2蜂蜜中14种喹诺酮类药物残留量的测定液相色谱-串联质谱法455 11.2.3牛奶和奶粉中7种喹诺酮类药物残留量的测定液相色谱-串联质谱法465 参考文献471 12四环素类药物479 12.1概述479 12.1.1理化性质与用途479 12.1.2代谢和毒理学481 12.1.3最大允许残留限量482 12.1.4残留分析技术483 12.2公定方法497 12.2.1蜂蜜中土霉素、四环素、金霉素、强力霉素残留量的测定液相色谱-串联质谱法497 12.2.2蜂蜜中土霉素、四环素、金霉素、强力霉素残留量的测定液相色谱-紫外检测法504 12.2.3可食动物肌肉中土霉素、四环素、金霉素、强力霉素残留量的测定液相色谱-紫外检测法509 12.2.4河豚鱼、鳗鱼中土霉素、四环素、金霉素、强力霉素残留量的测定液相色谱-紫外检测法512 12.2.5牛奶和奶粉中土霉素、四环素、金霉素、强力霉素残留量的测定液相色谱-紫外检测法516 参考文献521 13镇静剂类药物527 13.1概述527 13.1.1理化性质与用途527 13.1.2代谢和毒理学533 13.1.3最大允许残留限量534 13.1.4残留分析技术535 13.2公定方法549 13.2.1猪肾和肌肉组织、牛奶和奶粉中8种镇定剂残留量的测定液相色谱-串联质谱法549 参考文献559 14吡唑酮类药物564 14.1概述564 14.1.1理化性质与用途564 14.1.2代谢和毒理学566 14.1.3最大允许残留限量568 14.1.4残留分析技术569 14.2公定方法580 14.2.1牛和猪肌肉中安乃近代谢物残留量的测定液相色谱-串联质谱法580 14.2.2牛奶和奶粉中安乃近代谢物残留量的测定液相色谱-串联质谱法586 参考文献593 15喹 啉类药物596 15.1概述596 15.1.1理化性质与用途596 15.1.2代谢和毒理学598 15.1.3最大允许残留限量601 15.1.4残留分析技术601 15.2公定方法614 15.2.1牛、猪肝脏和肌肉中卡巴氧和喹乙醇及代谢物残留量的测定液相色谱-串联质谱法614 15.2.2牛奶和奶粉中卡巴氧和喹乙醇代谢物残留量的测定液相色谱-串联质谱法619 参考文献623 16硝基咪唑类药物627 16.1概述627 16.1.1理化性质与用途627 16.1.2代谢和毒理学629 16.1.3最大允许残留限量630 16.1.4残留分析技术630 16.2公定方法642 16.2.1牛奶和奶粉中甲硝唑、洛硝哒唑、二甲硝唑及其代谢物残留量的测定液相色谱-串联质谱法642 16.2.2蜂蜜中甲硝唑、洛硝哒唑、二甲硝咪唑残留量的测定液相色谱-串联质谱法648 16.2.3蜂王浆及冻干粉中9种硝基咪唑类药物残留量的测定液相色谱-串联质谱法653 参考文献661 17苯并咪唑类药物665 17.1概述665 17.1.1理化性质与用途665 17.1.2代谢和毒理学669 17.1.3最大允许残留限量670 17.1.4残留分析技术671 17.2公定方法684 17.2.1牛奶和奶粉中5种苯并咪唑类药物残留量的测定液相色谱-串联质谱法684 17.2.2河豚鱼、鳗鱼和烤鳗中16种苯并咪唑类药物残留量的测定液相色谱-串联质谱法691 参考文献698 18咪唑骈噻唑类药物703 18.1概述703 18.1.1理化性质与用途703 18.1.2代谢和毒理学704 18.1.3最大允许残留限量705 18.1.4残留分析技术706 18.2公定方法711 18.2.1牛奶和奶粉中左旋咪唑残留量的测定液相色谱-串联质谱法711 参考文献717 19硫脲嘧啶类药物720 19.1概述720 19.1.1理化性质与用途720 19.1.2代谢和毒理学722 19.1.3最大允许残留限量723 19.1.4残留分析技术723 19.2公定方法736 19.2.1牛甲状腺和牛肉中5种硫脲嘧啶类药物残留量的测定液相色谱-串联质谱法736 19.2.2动物源性食品中8种甲状腺拮抗剂残留量的测定高效液相色谱-串联质谱法742 参考文献748 20聚醚类药物751 20.1概述751 20.1.1理化性质与用途751 20.1.2代谢和毒理学754 20.1.3最大允许残留限量754 20.1.4残留分析技术756 20.2公定方法765 20.2.1牛奶和奶粉中6种聚醚类抗生素残留量的测定液相色谱-串联质谱法765 参考文献773 21阿维菌素类药物777 21.1概述777 21.1.1理化性质与用途777 21.1.2代谢和毒理学780 21.1.3最大允许残留限量781 21.1.4残留分析技术782 21.2公定方法792 21.2.1牛肝和牛肉中4种阿维菌素类药物残留量的测定液相色谱-串联质谱法792 21.2.2牛奶和奶粉中4种阿维菌素类药物残留量的测定液相色谱-串联质谱法796 21.2.3河豚鱼、鳗鱼和烤鳗中4种阿维菌素类药物残留量的测定液相色谱-串联质谱法801 参考文献805 22兽药多类别多组分残留810 22.1概述810 22.1.1前处理方法810 22.1.2测定方法813 22.2兽药精确质量数据库的建立与碎裂机理研究815 22.2.1试剂和材料816 22.2.2标准品和储备溶液816 22.2.3仪器与设备816 22.2.4液相色谱条件817 22.2.5质谱条件817 22.2.6兽药种类的确定817 22.2.7数据库的构建817 22.2.8质谱解析及裂解规律819 22.2.9小结834 22.3实验室内部方法834 22.3.1猪肉、牛肉和羊肉中55种兽药多组分残留测定液相色谱-串联质谱法834 22.3.2蜂蜜中40种兽药多组分残留测定液相色谱-四极杆-飞行质谱法844 22.3.3奶粉中100种兽药多组分残留测定液相色谱-四极杆-飞行质谱法858 参考文献877 Contents Preface 1β-Agonists1 1.1General Overview1 1.1.1Physicochemical property and pharmaceutical use1 1.1.2Metabolism and toxicology6 1.1.3Maximum residue limits, MRLs7 1.1.4Analytical technology7 1.2Official method15 1.2.1Determination of 12 β-agonists residues in fugu, eel, baked eel, milk and milk powder by LC-MS/MS15 References25 2Sulfonamides27 2.1General overview27 2.1.1Physicochemical property and pharmaceutical use27 2.1.2Metabolism and toxicology 27 2.1.3Maximum residue limits, MRLs31 2.1.4Analytical technology33 2.2Official method49 2.2.1Determination of 18 sulfonamides residues in fugu and eel by LC-MS/MS49 2.2.2Determination of 18 sulfonamide residues in royal jelly by LC-MS/MS57 2.2.3Determination of 16 sulfonamide residues in livestock and poultry muscles by LC-MS/MS62 2.2.4Determination of 16 sulfonamide residues in honey by LC-MS/MS67 2.2.5Determination of 16 sulfonamide residues in milk and milk powder by LC-MS/MS72 References79 3Aminoglycosid86 3.1General Overview86 3.1.1Physicochemical property and pharmaceutical use86 3.1.2Metabolism and toxicology88 3.1.3Maximum residue limits, MRLs89 3.1.4Analytical technology90 3.2Official method100 3.2.1Determination of streptomycin, dihydrostreptomycin and kanamycin residues in milk powder, milk, fugu, eel and royal jelly by LC-MS/MS100 3.2.2Determination of streptomycin, dihydrostreptomycin and kanamycin residues in honey by LC-MS/MS108 References110 4Chloramphenicol115 4.1General Overview115 4.1.1Physicochemical property and pharmaceutical use115 4.1.2Metabolism and toxicology116 4.1.3Maximum residue limits, MRLs118 4.1.4Analytical technology118 4.2Official method143 4.2.1Determination of chloramphenicol, thiamphenicol and florfenicol residues in fugu, eel and bakedeel by LC-MS/MS143 4.2.2Determination of chloramphenicol, thiamphenicol and florfenicol residues in edible animal muscles,liver and aquatic products by LC-MS/MS149 References153 5β-Lactams161 5.1General overview161 5.1.1Physicochemical property and pharmaceutical use161 5.1.2Metabolism and toxicology165 5.1.3Maximum residue limits, MRLs166 5.1.4Analytical technology166 5.2Official method180 5.2.1Determination of 9 penicillin residues in livestock and poultry muscles by LC-MS/MS180 5.2.2Determination of 9 penicillin residues in milk and milk powder by LC-MS/MS187 5.2.3Determination of 9 penicillin residues in fugu and eel by LC-MS/MS193 5.2.4Determination of 6 penicillin residues in honey by LC-MS/MS198 5.2.5Determination of 5 cephalosporin residues in honey by LC-MS/MS204 5.2.6Determination of 5 cephalosporin residues in fugu and eel by LC-MS/MS210 5.2.7Determination of 4 cephalosporin residues in milk and milk powder by LC-MS/MS213 References216 6Macrolides and lincosamides220 6.1General overview220 6.1.1Physicochemical property and pharmaceutical use222 6.1.2Metabolism and toxicology223 6.1.3Maximum residue limits, MRLs225 6.1.4Analytical technology228 6.2Official method236 6.2.1Determination of 9 macrolide and lincosamide residues in livestock and poultry muscles by LC-MS/MS236 6.2.2Determination of 8 macrolide and lincosamide residues in honey by LC-MS/MS243 6.2.3Determination of 8 macrolide residues in royal jelly and lyophilized royal jelly power by LC-MS/MS249 6.2.4Determination of 8 macrolide and lincosamide residues in fugu and eel by LC-MS/MS255 6.2.5Determination of 8 macrolide residues in milk and milk powder by LC-MS/MS261 References266 7Nitrofuran metabolites271 7.1General overview271 7.1.1Physicochemical property and pharmaceutical use271 7.1.2Metabolism and toxicology272 7.1.3Maximum residue limits, MRLs274 7.1.4Analytical technology274 7.2Official method282 7.2.1Determination of nitrofuran metabolite residues in animal original food by LC-MS/MS282 References294 8Anabolic steroids298 8.1General overview298 8.1.1Physicochemical property and pharmaceutical use298 8.1.2Metabolism and toxicology303 8.1.3Maximum residue limits, MRLs303 8.1.4Analytical technology 304 8.2Official method321 8.2.1Determination of testosterone, epi-testosterone and progesterone residues in bovine liver and muscletissues by LC-MS/MS321 8.2.2Determination of melengestrol acetate, chlormadinone acetate and megestrol acetate residues in milkand milk powder by LC-MS/MS326 8.2.3Determination of α-trenbolone, β-trenbolone, nortestosterone and epi-nortestosterone residues in milkand milk powder by LC-MS/MS330 8.2.4Determination of α-trenbolone, β-trenbolone residues in bovine muscle, liver and kidney byLC-MS/MS336 8.2.5Determination of α-trenbolone, β-trenbolone, nortestosterone and epi-nortestosterone residues in bovineurine by LC-MS/MS340 References345 9Inanabolic steroids350 9.1General overview350 9.1.1Physicochemical property and pharmaceutical use350 9.1.2Metabolism and toxicology352 9.1.3Maximum residue limits, MRLs354 9.1.4Analytical technology354 9.2Official method369 9.2.1Determination of zearalanol, zearalanone, diethylstilbestrol, hexestrol and dienoestrol multi-residuesin bovine and porcine liver, kidney and muscle by LC-MS/MS369 9.2.2Determination of zearalanol, diethylstilbestrol, hexestrol and dienoestrol multi-residues in bovine urineby LC-MS/MS376 9.2.3Determination of zearalanol, zearalanone, diethylstilbestrol, hexestrol and dienoestrol residues in fugu,eels and baked eel by LC-MS/MS379 9.2.4Determination of zearalanol, zearalanone, diethylstilbestrol, hexestrol and dienoestrol residues in milkand milk powder by LC-MS/MS384 9.2.5Determination of zeranol residues in animal original food by LC-MS/MS389 References393 10Glucocorticoids398 10.1General overview398 10.1.1Physicochemical property and pharmaceutical use398 10.1.2Metabolism and toxicology401 10.1.3Maximum residue limits, MRLs401 10.1.4Analytical technology402 10.2Official method412 10.2.1Determination of 9 glucocorticoid residues in fugu, eel and baked eel by LC-MS/MS412 References419 11Quinolones423 11.1General overview423 11.1.1Physicochemical property and pharmaceutical use423 11.1.2Metabolism and toxicology429 11.1.3Maximum residue limits, MRLs430 11.1.4Analytical technology433 11.2Official method447 11.2.1Determination of 15 fluoroquinolone residues in eel and eel product by LC-MS/MS447 11.2.2Determination of 14 fluoroquinolone residues in honey by LC-MS/MS455 11.2.3Determination of 7 fluoroquinolone residues in milk and milk powder by LC-MS/MS465 References471 12Tetracyclines479 12.1General overview479 12.1.1Physicochemical property and pharmaceutical use479 12.1.2Metabolism and toxicology481 12.1.3Maximum residue limits, MRLs482 12.1.4Analytical technology483 12.2Official method497 12.2.1Determination of oxytetracycline, tetracycline, chlortetracycline, and doxycycline residues in honeyby LC-MS/MS497 12.2.2Determination of oxytetracycline,tetracycline, chlortetracycline and doxycycline residues in honeyby LC-UV504 12.2.3Determination of oxytetracycline, tetracycline, chlortetracycline, and doxycycline residues in edibleanimal muscles by LC-UV509 12.2.4Determination of oxytetracycline, tetracycline, chlortetracycline, doxycycline residues in fugu andeel by LC-UV512 12.2.5Determination of oxytetracycline, tetracycline, chlortetracycline, and doxycycline residues in milkand milk powder by LC-UV516 References521 13Sedatives527 13.1General overview527 13.1.1Physicochemical property and pharmaceutical use527 13.1.2Metabolism and toxicology533 13.1.3Maximum residue limits, MRLs534 13.1.4Analytical technology535 13.2Official method549 13.2.1Determination of 8 sedative residues in porcine kidney, muscle tissues, milk and milk powderby LC-MS/MS549 References559 14Pyrazolones564 14.1General overview564 14.1.1Physicochemical property and pharmaceutical use564 14.1.2Metabolism and toxicology566 14.1.3Maximum residue limits, MRLs568 14.1.4Analytical technology569 14.2Official method580 14.2.1Determination of metabolite residues of dipyrone in bovine and porcine muscle tissues byLC-MS/MS580 14.2.2Determination of metabolite residues of dipyrone in milk and milk powder by LC-MS/MS586 References593 15Quinoxalines596 15.1General overview596 15.1.1Physicochemical property and pharmaceutical use596 15.1.2Metabolism and toxicology598 15.1.3Maximum residue limits, MRLs601 15.1.4Analytical technology601 15.2Official method614 15.2.1Determination of the residues of carbadox, olaquindox and related metabolites in bovine and porcineliver and muscle tissues by LC-MS/MS614 15.2.2Determination of the residues of metabolites of carbadox and olaquindox in milk and milkpowder by LC-MS/MS619 References623 16Nitroimidazoles627 16.1General overview627 16.1.1Physicochemical property and pharmaceutical use627 16.1.2Metabolism and toxicology629 16.1.3Maximum residue limits, MRLs630 16.1.4Analytical technology630 16.2Official method642 16.2.1Determination of metronidazole, ronidazole, dimetridazole residues in milk and milk powder byLC-MS/MS642 16.2.2Determination of metronidazole, ronidazole and dimetridazole residues in honey by LC-MS/MS648 16.2.3Determination of nitroimidazole residues in royal jelly and lyophilized royal jelly power by LC-MS/MS653 References661 17Benzimidazoles665 17.1General overview665 17.1.1Physicochemical property and pharmaceutical use665 17.1.2Metabolism and toxicology669 17.1.3Maximum residue limits, MRLs670 17.1.4Analytical technology671 17.2Official method684 17.2.1Determination of 5 benzimidazoles residues in milk and milk powder by LC-MS/MS684 17.2.2Determination of 16 benzimidazoles residues in fugu, eel and baked eel by LC-MS/MS691 References698 18Imidazothiazoles703 18.1General overview703 18.1.1Physicochemical property and pharmaceutical use703 18.1.2Metabolism and toxicology704 18.1.3Maximum residue limits, MRLs705 18.1.4Analytical technology706 18.2Official method711 18.2.1Determination of levamisole residues in milk and milk powder by LC-MS/MS711 References717 19Thioureas720 19.1General overview720 19.1.1Physicochemical property and pharmaceutical use720 19.1.2Metabolism and toxicology722 19.1.3Maximum residue limits, MRLs723 19.1.4Analytical technology723 19.2Official method736 19.2.1Determination of 5 thiourea residues in bovine thyroid and muscles by LC-MS/MS736 19.2.2Determination of 8 thyreostat residues in foodstuffs of animal origin by LC-MS/MS742 References748 20Polyethers751 20.1General overview751 20.1.1Physicochemical property and pharmaceutical use751 20.1.2Metabolism and toxicology754 20.1.3Maximum residue limits, MRLs754 20.1.4Analytical technology756 20.2Official method765 20.2.1Determination of 6 polyether antibiotics residues in milk and milk powder by LC-MS/MS765 References773 21Avermectins777 21.1General overview777 21.1.1Physicochemical property and pharmaceutical use777 21.1.2Metabolism and toxicology780 21.1.3Maximum residue limits, MRLs781 21.1.4Analytical technology782 21.2Official method792 21.2.1Determination of 4 avermectin residues in bovine liver and muscle tissues by LC-MS/MS792 21.2.2Determination of 4 avermectin residues in milk and milk powder by LC-MS/MS796 21.2.3Determination of 4 avermectin residues in fugu, eel and baked eel by LC-MS/MS801 References805 22Multi-classes of veterinary drug residues810 22.1General overview810 22.1.1Pretreatment method810 22.1.2Analytical method813 22.2Construction of accurate mass data bank and the research of fragmentation mechanism815 22.2.1Reagent and material816 22.2.2Standard and stock solution816 22.2.3Instrument816 22.2.4LC conditions817 22.2.5MS conditions817 22.2.6Confirmation of target drugs817 22.2.7Data bank construction817 22.2.8Mass spectra interpretation and fragmentation mechanism819 22.2.9Summary834 22.3Non-official method834 22.3.1Determination of 55 veterinary drug residues in pork, beef and mutton by LC-MS/MS834 22.3.2Determination of 40 veterinary drug residues in honey by LC-Q-TOFMS844 22.3.3Determination of 100 veterinary drug residues in milk powder by LC-Q-TOFMS858 References877
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